GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs12149862 | 1 | rs12149862 | chr16:69497203 | TERF2 | chr16:69389535-69419873:- | 0.14 | 3.45 | 0.000578 | Blood pressure (smoking interaction) |
| BRCA | cis | rs12149862 | 1 | rs12149862 | chr16:69497203 | VPS4A | chr16:69345287-69358945:+ | 0.12 | 3.76 | 0.000178 | Blood pressure (smoking interaction) |
| BRCA | cis | rs10043228 | 1 | rs12152964 | chr5:115609965 | COMMD10 | chr5:115420727-115628978:+ | 0.24 | 4.47 | 8.82E-6 | Asthma or chronic obstructive pulmonary disease |
| BRCA | cis | rs10043228 | 1 | rs12153717 | chr5:115571914 | COMMD10 | chr5:115420727-115628978:+ | 0.23 | 4.37 | 1.39E-5 | Asthma or chronic obstructive pulmonary disease |
| BRCA | cis | rs2274459 | 1 | rs12153877 | chr6:33765465 | IP6K3 | chr6:33689443-33714762:- | 0.29 | 5 | 6.66E-7 | Obesity (extreme) |
| BRCA | cis | rs1577917 | 1 | rs12154056 | chr6:86634094 | SNHG5 | chr6:86386726-86388451:- | -0.56 | -17.95 | 3.91E-63 | Response to antipsychotic treatment |
| BRCA | cis | rs7523273 | 1 | rs12184327 | chr1:207978780 | C4BPA | chr1:207277511-207318308:+ | -0.13 | -3.82 | 0.000142 | Schizophrenia |
| BRCA | cis | rs12188300 | 1 | rs12188300 | chr5:158829527 | TTC1 | chr5:159436180-159492549:+ | -0.23 | -3.65 | 0.000279 | Psoriatic arthritis |
| BRCA | cis | rs12196860 | 1 | rs12189567 | chr6:55933942 | COL21A1 | chr6:55921389-56258892:- | -0.38 | -6.94 | 6.82E-12 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12189571 | chr6:55933987 | COL21A1 | chr6:55921389-56258892:- | -0.38 | -6.94 | 6.82E-12 | Psychosis (atypical) |
| BRCA | cis | rs2274459 | 1 | rs12189725 | chr6:33703394 | IP6K3 | chr6:33689443-33714762:- | 0.25 | 4.54 | 6.23E-6 | Obesity (extreme) |
| BRCA | cis | rs12216499 | 1 | rs12190146 | chr6:159414155 | RSPH3 | chr6:159398268-159421198:- | 0.23 | 4.07 | 4.95E-5 | Bladder cancer (smoking interaction) |
| BRCA | cis | rs1577917 | 1 | rs12190598 | chr6:86686074 | SNHG5 | chr6:86386726-86388451:- | -0.56 | -16.96 | 2.68E-57 | Response to antipsychotic treatment |
| BRCA | cis | rs1577917 | 1 | rs12190604 | chr6:86716215 | SNHG5 | chr6:86386726-86388451:- | -0.59 | -18.06 | 7.99E-64 | Response to antipsychotic treatment |
| BRCA | cis | rs12196860 | 1 | rs12190671 | chr6:55959857 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.8 | 1.71E-11 | Psychosis (atypical) |